Researchers from the National Institutes of Health have announced the discovery of a natural antibody that prevents HIV, the virus believed to cause AIDS, from infecting human beings.
Antibodies are naturally occurring proteins that identify and destroy foreign elements such as bacteria or viruses. The discovery came as researchers at the National Cancer Institute, which is part of NIH, were investigating antibody genes in relation to the outer shell protein of HIV.
The discovery could lead to new drugs, said researcher Dimiter S. Dimitrov. “The antibody fragment that we identified, m36, could have potential in the development of a therapeutic drug that inhibits HIV. Further research with this molecule also could offer insight about how the virus infects cells and how it evades neutralization by the immune system.”
“We found an antibody fragment that exhibited the ability to neutralize HIV,” Dimitrov said.
Dimitrov’s research can be read here. The study appears online Oct. 20 in Proceedings of the National Academy of Sciences.
“In the United States, it is estimated that more than 50 percent of patients who are receiving antiretroviral therapy for their HIV infection carry strains of the virus that are resistant to treatment with at least one of the currently available drugs,” said NCI Director John E. Niederhuber, M.D. “The development of new drugs against HIV is an urgent public health need.”